Arylpurine derivatives mimicking sinefungin and their evaluation as inhibitors of Zika virus methyltransferase
Natalia del Río, Iván Arribas, José-María Orduña, Priscila Sutto-Ortiz, Johan Neyts, Suzanne Kaptein, Etienne Decroly, Eva-María Priego and María-Jesús Pérez-Pérez
Submitted
Mapping the impact of 1’-, 2’- and 4’-nucleotide modifications onto the RSV RNA-dependent RNA polymerase
Priscila Sutto-Ortiz, Barbara Selisko, François Ferron, Jean-Pierre Sommadossi, Adel Moussa, Steven Good, Bruno Canard, and Etienne Decroly
Submitted
A robust mouse model of human parainfluenza 3 virus infection and efficacy of GS-441524, the parent nucleoside of remdesivir, against lung pathology
Yuxia Lin, Mona Khan, Birgit Weynand, Manon Laporte, Frank Coenjaerts, Darius Babusis, John P Bilello, Peter Mombaerts, Dirk Jochmans, Johan Neyts.
Nat Commun. 2024 Sep 5;15(1):7765. doi: 10.1038/s41467-024-52071-5
Novel potent inhibitors of the SARS-CoV-2 NSP13 helicase identified through a new fragment-based pharmacophore virtual screening workflow
Janssen (J&J). Journal of Computational Chemistry.
In press 2025
The Combination of GS-441524 (Remdesivir) and Ribavirin Results in a Potent Antiviral Effect Against Human Parainfluenza Virus 3 Infection in Human Airway Epithelial Cell Cultures and in a Mouse Infection Mode
Yuxia Lin, Birgit Weynand, Xin Zhang, Manon Laport, Dirk Jochmans, Johan Neyts
Viruses. 2025 Jan 26;17(2):172. doi: 10.3390/v17020172. PMID: 40006927; PMCID: PMC11860817.
Revealing protein structures: crystallization of protein-ligand complexes - co-crystallization and crystal soaking
Barbora Kascakova, Anna Koutska, Ivana Kuta Smatanova
FEBS Open Bio. 2025 Apr;15(4):542-550. doi: 10.1002/2211-5463.13913. Epub 2024 Oct 20. PMID: 39428257; PMCID: PMC11961386.