Scientific publications

1. A coronavirus assembly inhibitor that targets the viral membrane protein
   Manon Laporte, Dirk Jochmans, Dorothée Bardiot, Lowiese Desmarets, Oliver J. Debski-Antoniak, Giulia Mizzon, Rana Abdelnabi, Pieter Leyssen, Winston Chiu, Zhikuan Zhang, Norimichi Nomura, Sandro Boland, Umeharu Ohto, Yannick Stahl, Jurgen Wuyts, Steven De Jonghe, Annelies Stevaert, Martijn J. van Hemert, Brenda W. Bontes, Patrick Wanningen, G. J. Mirjam Groenewold, Aneta Zegar, Katarzyna Owczarek, Sanjata Joshi, Mohamed Koukni, Philippe Arzel, Hugo Klaassen, Jean-Christophe Vanherck, Ilse Vandecaetsbeek, Niels Cremers, Kim Donckers, Thibault Francken, Tina Van Buyten, Jasper Rymenants, Joost Schepers, Krzysztof Pyrc, Rolf Hilgenfeld, Jean Dubuisson, Berend-Jan Bosch, Frank Van Kuppeveld, Cecilia Eydoux, Etienne Decroly, Bruno Canard, Lieve Naesens, Birgit Weynand, Eric J. Snijder, Sandrine Belouzard, Toshiyuki Shimizu, Ralf Bartenschlager, Daniel L. Hurdiss, Arnaud Marchand, Patrick Chaltin & Johan Neyts
   DOI: Nature (2025). https://doi.org/10.1038/s41586-025-08773-x
   
   

2. Arylpurine derivatives mimicking sinefungin and their evaluation as inhibitors of Zika virus methyltransferase
   Natalia del Río, Iván Arribas, José-María Orduña, Priscila Sutto-Ortiz, Johan Neyts, Suzanne Kaptein, Etienne Decroly, Eva-María Priego and María-Jesús Pérez-Pérez 
   Submitted

3. Mapping the impact of 1’-, 2’- and 4’-nucleotide modifications onto the RSV RNA-dependent RNA polymerase
   Priscila Sutto-Ortiz, Barbara Selisko, François Ferron, Jean-Pierre Sommadossi, Adel Moussa, Steven Good, Bruno Canard, and Etienne Decroly
   Submitted

4. A robust mouse model of human parainfluenza 3 virus infection and efficacy of GS-441524, the parent nucleoside of remdesivir, against lung pathology
   Yuxia Lin, Mona Khan, Birgit Weynand, Manon Laporte, Frank Coenjaerts, Darius Babusis, John P Bilello, Peter Mombaerts, Dirk Jochmans, Johan Neyts.
   Nat Commun. 2024 Sep 5;15(1):7765. doi: 10.1038/s41467-024-52071-5 

5. Novel potent inhibitors of the SARS-CoV-2 NSP13 helicase identified through a new fragment-based pharmacophore virtual screening workflow
   Janssen (J&J). Journal of Computational Chemistry.
   In press 2025

6. The Combination of GS-441524 (Remdesivir) and Ribavirin Results in a Potent Antiviral Effect Against Human Parainfluenza Virus 3 Infection in Human Airway Epithelial Cell Cultures and in a Mouse Infection Mode
   Yuxia Lin, Birgit Weynand, Xin Zhang, Manon Laport, Dirk Jochmans, Johan Neyts
   Viruses. 2025 Jan 26;17(2):172. doi: 10.3390/v17020172. PMID: 40006927; PMCID: PMC11860817. 

7. Revealing protein structures: crystallization of protein-ligand complexes - co-crystallization and crystal soaking
   Barbora Kascakova, Anna Koutska, Ivana Kuta Smatanova
   FEBS Open Bio. 2025 Apr;15(4):542-550. doi: 10.1002/2211-5463.13913. Epub 2024 Oct 20. PMID: 39428257; PMCID: PMC11961386.